Electrochemical Trifluoromethylthiolation and Spirocyclization of Alkynes with AgSCF3: Access to SCF3-Containing Spiro[5,5]trienones

Autor:	Lei Wang, Cai-Yun Chen, Wen-Chao Yang, Yu Sun, Ming-Ming Zhang
Rok vydání:	2021
Předmět:	Chemistry Organic Chemistry Physical and Theoretical Chemistry Persulfate Electrochemistry Biochemistry Combinatorial chemistry Radical cyclization
Zdroj:	Organic Letters. 23:6691-6696
ISSN:	1523-7052 1523-7060
DOI:	10.1021/acs.orglett.1c02260
Popis:	A novel and efficient strategy for trifluoromethylthiolation and dearomatization of activated alkynes with stable and readily available AgSCF3 has been developed. Reported herein is the unprecedented electrochemical generation of the SCF3 radical in the absence of persulfate for the synthesis of SCF3-containing spiro[5,5]trienones in good yields via a 6-exo-trig radical cyclization.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f4a62987b27e7de24fa6d5ccbb90c739 https://doi.org/10.1021/acs.orglett.1c02260 Zobrazit plný text záznamu