Inhibition of tumour-promoter-enhanced32Pi-incorporation into cellular phospholipids by flavonols from genusChrysosplenium

Autor:	Akio Iwashima, Munehisa Arisawa, Atsuko Nishino, Yoshiko Satomi, Mineo Shimizu, Hoyoku Nishino
Rok vydání:	1995
Předmět:	Pharmacology chemistry.chemical_classification biology Saxifragaceae Chrysosplenium Pharmacognosy biology.organism_classification In vitro HeLa Flavonols Biochemistry chemistry Cell culture Potency
Zdroj:	Phytotherapy Research. 9:222-224
ISSN:	1099-1573 0951-418X
Popis:	Flavonol aglycones from the genus Chrysosplenium showed potential antitumour-promoter activity. Three flavonols, oxyayanin A and chrysosplenols D and E, markedly inhibited the incorporation of 32Pi into phospholipids of confluent HeLa cells stimulated by 12-O-tetradecanoylphorbol-13-acetate (TPA), a potent tumour promoter. The potency of the flavonols proved to be similar to those of other antitumour-promoting flavonoids.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f49595f3f2a3f935fed3f11718e2f8e4 https://doi.org/10.1002/ptr.2650090314 Zobrazit plný text záznamu Plný text