Novel Piperazinyl-Quinazoline-4-one Analogs: Design, Synthesis and Evaluation of In Vitro Biological Activity

Autor:	Jignesh P. Raval, Deep R. Naik, Kruti Navin Myangar, Tarunkumar Nanjibhai Akhaja, Rita Patel
Rok vydání:	2012
Předmět:	Antifungal biology medicine.drug_class Biological activity General Medicine biology.organism_classification Combinatorial chemistry In vitro Mycobacterium tuberculosis chemistry.chemical_compound Design synthesis chemistry medicine Quinazoline
Zdroj:	Chemical Science Transactions. 1:688-696
ISSN:	2278-3318 2278-3458
DOI:	10.7598/cst2012.243
Popis:	A series of novel 2-(4-substituted-piperazinyl-methyl)-3-(N-isonicotinamide-yl)-quinazoline- 4-one 4a-l were designed, synthesized, characterized and evaluated for in vitro antitubercular, antibacterial and antifungal activity. Compounds 4f , 4h and 4l exhibited excellent antitubercular activity against mycobacterium tuberculosis H 37 Rv .
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f491c8d388fc787070b6229249e49b00 https://doi.org/10.7598/cst2012.243 Zobrazit plný text záznamu