| Autor: |
Andrew I. Yang, Drew Parker, Ragini Verma, Gordon H. Baltuch, Anupa Ambili Vijayakumari, Aunapu D, Ronald L. Wolf, Ashwin G. Ramayya |
| Rok vydání: |
2021 |
| Předmět: |
|
| Popis: |
BackgroundThe ventral intermediate (VIM) nucleus of the thalamus is the main target for lesioning using magnetic resonance imaging (MRI) guided focused ultrasound (MRgFUS) or deep brain stimulation (DBS). Targeting of VIM still depends on standard stereotactic coordinates, which do not account for inter-individual variability. Several approaches have been proposed including visualization of dentato-rubro-thalamic tract (DRTT) using diffusion tensor imaging tractography.ObjectiveTo compare probabilistic tracking of DRTT with deterministic tracking of DRTT and stereotactic coordinates to identify the most appropriate approach to target VIM.MethodsIn this retrospective study, we assessed the VIM targeted using stereotactic coordinates, deterministic and probabilistic tracking of DRTT in 19 patients with essential tremor who underwent DBS with VIM targeted using microelectrode recordings. We subsequently determined the positions of VIM derived from these three approaches and compared with that of DBS lead position using paired samplet-tests.ResultsThe probabilistic tracking of DRTT was significantly anterior to the lead (1.45 ± 1.61 mm (P< 0.0001)), but not in the medial/lateral position (−0.29±2.42 mm (P=0.50)). Deterministic tracking of DRTT was significantly lateral (2.16 ± 1.94 mm (P< 0.0001)) and anterior to the lead (1.66 ± 2.1 mm (P< 0.0001)). The stereotactic coordinates were significantly lateral (2.41 ± 1.41 mm (P< 0.0001)) and anterior (1.23 ± 0.89 mm (P< 0.0001)) to the lead.ConclusionProbabilistic tracking of DRTT was found to be superior in targeting VIM compared to deterministic tracking and stereotactic coordinates. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
