Angionorm Complex Herbal Preparation Constituents Identified by High Performance Liquid Chromatography-Mass Spectrometry

Autor:	V. K. Kolkhir, E. S. Mel’nikov, P. A. Struchkov, Vladimir L. Beloborodov, I. V. Voskoboinikova
Rok vydání:	2019
Předmět:	Pharmacology chemistry.chemical_classification Chromatography biology 010405 organic chemistry Elution Rosa canina Hyperoside biology.organism_classification 01 natural sciences High-performance liquid chromatography Crataegus 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound chemistry Triterpene Drug Discovery Glycyrrhiza Liquiritin
Zdroj:	Pharmaceutical Chemistry Journal. 52:980-985
ISSN:	1573-9031 0091-150X
Popis:	Angionorm is an original Russian preparation based on the dried aqueous EtOH (25%) extract of a herbal mixture containing horse chestnuts (Aesculus hippocastanum L.), licorice roots (Glycyrrhiza glabra L.), hawthorn fruit (Crataegus), and dog-rose hips (Rosa canina). Areversed-phase HPLC-MS-MS procedure with gradient elution was developed to identify the main constituents in extracts of the mixture and each raw material type. Standards helped to identify 15 compounds of various classes (phenolic and hydroxycinnamic acids and their esters, flavonoids, flavonoid glycosides, triterpene saponins). Peaks of hyperoside, liquiritin, â-glycyrrhizic acid, and escin isomers were identified using MRM transitions, elution order, and literature data. Herbal sources of identified constituents were determined. Marker compounds characteristic of each raw-material type in the mixture extract were proposed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f48ad2d9454a34966d42e03f3471734b https://doi.org/10.1007/s11094-019-01937-w Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.