Brief Communication : Adriamycin-Induced Cardiac Damage in the Mouse: A Small-Animal Model of Cardiotoxicity

Autor:	Robert C. Young, David M. Young, Frieda Bostick, Harry M. Olson, Stephen H. Rosenoff
Rok vydání:	1975
Předmět:	Cancer Research Cardiotoxicity Pathology medicine.medical_specialty Necrosis business.industry Cardiomyopathy Degeneration (medical) Mitochondrion Pharmacology medicine.disease Tissue Degeneration Oncology Toxicity Medicine Doxorubicin medicine.symptom business medicine.drug
Zdroj:	JNCI: Journal of the National Cancer Institute. 55:191-194
ISSN:	1460-2105 0027-8874
DOI:	10.1093/jnci/55.1.191
Popis:	After one dose of adriamycin, a subacute cardiomyopathy was observed in the mouse by both light and electron microscopy. The microscopic alterations were characterized by single-cell necrosis and mitochondrial degeneration. These lesions were similar to those seen in man and shortly preceded fatal toxicity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f4599a168bd7554b12a57f885617ae19 https://doi.org/10.1093/jnci/55.1.191 Zobrazit plný text záznamu