The effect of taurine on the ion transport system in mitochondria

Autor: Natalia V. Belosludtseva, S. V. Murzaeva, L. Gavrovskaya, Galina D. Mironova
Rok vydání: 2008
Předmět:
Zdroj: Biophysics. 53:515-518
ISSN: 1555-6654
0006-3509
DOI: 10.1134/s0006350908060080
Popis: The effect of taurine on the ATP-dependent mitochondrial swelling that characterizes the activity of mitochondrial ATP-dependent K+ channel and the formation of Ca2+-dependent pores, different in sensitivity to cyclosporin A, has been studied in rat liver mitochondria. It has been shown that taurine in micromolar concentrations (0.5–125 μM) stimulates the energy-dependent swelling of mitochondria. Taurine in physiological concentrations (0.5–20 mM) has no effect on the ATP-dependent swelling and the formation of cyclosporin A-insensitive Pal/Ca2+-activated pore in mitochondria. Taurine in these concentrations increased the rate of cyclosporin A-sensitive swelling of mitochondria induced by Ca2+ and Pi and reduced the Ca2+ capacity of mitochondria. The different effects of physiological taurine concentrations on the ATP-dependent transport of K+ and Ca2+ ions in mitochondrial membranes as compared with cell membranes are discussed.
Databáze: OpenAIRE
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