BLADDER CARCINOMA;
| Autor: | Anila Qureshi, Mohammad Ahmed Azmi, Muhammad Hanif, Amin Fahim |
|---|---|
| Rok vydání: | 2016 |
| Zdroj: | The Professional Medical Journal. 23:509-515 |
| ISSN: | 2071-7733 1024-8919 |
| DOI: | 10.29309/tpmj/2016.23.05.1573 |
| Popis: | Objectives: To determine the micro-RNA-145 expression in bladder cancerpatients when compared with controls and clinicopathological parameters. Study design: Acase control study. Place of Study: Samples were collected from Jinnah Postgraduate MedicalCenter Karachi and Civil Hospital Karachi. Duration of Study: January 2014 to December2014. Materials and Methods: Total of 180 patients of bladder carcinoma were divided intothree groups according to WHO/1998 classification system. PUNLMP in group-I, PUCLG ingroup-II, PUCHG in group-III were compared with 60 healthy controls in group-IV. Results:The results showed that miR-145 expression was decreased in patients with bladder cancerwhen compared with controls. Down regulation was more obvious in BC cases with increasinggrade. A significant correlation was found between the expression of miR-145 with microscopichematuria, cystoscopy and staging. Whereas no association was found with age, frequency,urgency, flank pain, gross hematuria, urine pH, and ultrasound. Conclusion: miR-145 is downregulated in BC patients with significant correlation with microscopic hematuria, cystoscopyand staging. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|