Cell cycle-specific variation of intercellular plasminogen activator activity in cultured human alveolar epithelial carcinoma and rat hepatoma cells

Autor: Jean-Jacques Befort, Joseph G. Bieth, Georges Orfanoudakis, Driss Zaoui
Rok vydání: 1989
Předmět:
Zdroj: Biology of the Cell. 65:297-300
ISSN: 0248-4900
DOI: 10.1111/j.1768-322x.1989.tb00802.x
Popis: Plasminogen activator activity was demonstrated in two carcinoma cell lines: A549 cells derived from a human alveolar epithelial carcinoma; and ZHC cells derived from a rat hepotoma. Beoth cells had intracellular plasminogen activator activity throughout their cell cycles and in each case this activity reached a maxumum. For A549 cells the maximal activity took place either during the G2 phase or in the course of the S to G2 transition, suggesting that plasminogen activator might play a role in cell division. For ZHC cells, the maximal activity occurred at the start of the S phase, suggesting that in these cells plasminogen activator might be involved in DNA replication.
Databáze: OpenAIRE