Comparative between IMRT and 3D-CRT for upper GI malignancies

Autor: M. Iborra Oquendo, A. Seguro Fernandez, A. Ureña Llinares, L. Díaz Gómez
Rok vydání: 2016
Předmět:
Zdroj: Physica Medica. 32:296
ISSN: 1120-1797
DOI: 10.1016/j.ejmp.2016.07.131
Popis: Introduction Adjuvant therapy after surgery in patients diagnosed with tumors of the upper abdominal area is a standard of care. In the field of radiotherapy is a challenge for proximity to PTV of multiple organs at risk (OARs) including spinal cord, liver, kidneys, lungs or heart. Purpose Our goal of this study is to demonstrate the benefit of intensity modulated radiotherapy (IMRT) over 3D conformal therapy (3D-CRT) on OAR protection and improvement in planning target volume (PTV) coverage. Materials and methods 11 patients were selected with upper digestive tract neoplasms with adjuvant treatment indication. The 3D-CRT technique involved two lateral fields and one or two oblique, with different table angles to avoid most volume of kidneys. IMRT technique involved several multi-field coplanar inverse planning. The prescription dose was 45 Gy in 25 fractions. Dose–volume histograms, dose homogeneity and dose to OAR were evaluated. Results Both techniques are adequate with good coverage in the V95 with no evident differences in PTV dose homogeneity. IMRT was superior to 3DCRT with improvements in reducing the volume of both kidneys in the low dose region (V15) and liver as well (V30), achieving a lower spinal cord maximum dose. This can be explained by more number of the beams used in the IMRT technique. However, there were no significant improvements in PTV coverage. Conclusion IMRT is a recommended technique for better protection of organs at risk without improving PTV coverages for upper GI malignancies. No conflict of interest.
Databáze: OpenAIRE
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