Calculated and Experimental Low-Energy Conformations of Cyclic Urea HIV Protease Inhibitors
Autor: | George V. De Lucca, Wayne F. Daneker, Paul E. Aldrich, Y. Ru, C.-H. Chang, Charles J. Eyermann, C.Nicholas Hodge, Edward R. Holler, Francis J. Woerner, and Joseph C. Calabrese, Robert F. Kaltenbach, Fernandez Ch, Prabhakar K. Jadhav, Patrick Y.S. Lam, George Emmett |
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Rok vydání: | 1998 |
Předmět: |
Quantitative Biology::Biomolecules
Aqueous solution Protease medicine.medical_treatment General Chemistry Ligand (biochemistry) Biochemistry Small molecule Catalysis Quantitative Biology::Cell Behavior Quantitative Biology::Subcellular Processes Maxima and minima chemistry.chemical_compound Crystallography Colloid and Surface Chemistry Low energy chemistry Urea medicine HIV Protease Inhibitor |
Zdroj: | Journal of the American Chemical Society. 120:4570-4581 |
ISSN: | 1520-5126 0002-7863 |
DOI: | 10.1021/ja972357h |
Popis: | One important factor influencing the affinity of a flexible ligand for a receptor is the internal strain energy required to attain the bound conformation. Calculation of fully equilibrated ensembles of bound and free ligand and receptor conformations are computationally not possible for most systems of biological interest; therefore, the qualitative evaluation of a novel structure as a potential high-affinity ligand for a given receptor can benefit from taking into account both the bound and unbound (usually aqueous) low-energy geometries of the ligand and the difference in their internal energies. Although many techniques for computationally generating and evaluating the conformational preferences of small molecules are available, there are a limited number of studies of complex organics that compare calculated and experimentally observed conformations. To assess our ability to predict a priori favored conformations of cyclic HIV protease (HIV-1 PR) inhibitors, conformational minima for nine 4,7-bis(phen... |
Databáze: | OpenAIRE |
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