A Scalable Zinc Activation Procedure Using DIBAL-H in a Reformatsky Reaction

Autor:	Liang Jessica, Joel Slade, Michael J. Girgis, Kapa Prasad, Zhengming Du
Rok vydání:	2009
Předmět:	Exothermic reaction Reaction calorimeter Chemistry Reagent Organic Chemistry Induction time chemistry.chemical_element Zinc Physical and Theoretical Chemistry Activation method Reformatsky reaction Photochemistry Combinatorial chemistry
Zdroj:	Organic Process Research & Development. 13:1094-1099
ISSN:	1520-586X 1083-6160
Popis:	The highly exothermic nature of Reformatsky reagent formation and the reported unpredictability of the induction time for its formation pose challenging problems for scaling up Reformatsky reactions. A zinc-activation procedure using DIBAL-H was developed and investigated using reaction calorimetry along with subsequent parts of the process. This procedure was shown to have important advantages for scale-up relative to previous zinc activation methods, including an immediate start of Reformatsky reagent formation with addition-controlled reaction. Calorimetric analysis was especially useful in specifying quickly a suitable temperature for Reformatsky reagent formation. The process was scaled up successfully.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f44185a39272e814808a921f1db0e920 https://doi.org/10.1021/op900192m Zobrazit plný text záznamu