Effect of apolipoproteins on the induction of hepatic steatosis in rats
| Autor: | John B. Hanks, L. Jakoi, William C. Meyers, Frank A. Shelburne, Steven H. Quarfordt |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Isolated liver
Apolipoprotein E medicine.medical_specialty Very low-density lipoprotein Hepatology Triglyceride Chemistry Gastroenterology medicine.disease In vitro chemistry.chemical_compound Endocrinology Rat liver Internal medicine Emulsion medicine lipids (amino acids peptides and proteins) Steatosis |
| Zdroj: | Gastroenterology. 80:149-153 |
| ISSN: | 0016-5085 |
| Popis: | The incorporation of apolipoprotein E isolated from human very low density lipoproteins on a triglyceride emulsion produced a substantial increment in hepatic triglyceride after 1 h of in vitro perfusion through the isolated liver of a fasted rat. Both gross and microscopic morphology confirmed a substantial steatosis. Perfusions with triglyceride emulsions which contained no apolipoproteins resulted in a modest increment in hepatic triglyceride although considerably less than emulsions with the E protein, and no morphologic features of steatosis. The steatosis induced in the in vitro perfused fasted livers by the emulsions with E protein could be prevented when CIII-1 apoprotein was also incorporated on the emulsion. A fed rat liver perfused with the E-enriched emulsion accumulated significantly less triglyceride than the fasted preparation. These data suggest that the apoprotein patterns of the plasma triglyceride-rich lipoproteins are of considerable importance for the partition of triglyceride between liver and plasma. |
| Databáze: | OpenAIRE |
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