A methylenetetrahydrofolate reductase gene polymorphism in ischaemic stroke and in carotid artery stenosis
| Autor: | V. Kostulas, W.‐X. Huang, L. Lannfelt, Konstantinos Kostulas, G. Eggertsen, Jan Hillert, L Hagenfeldt, Milita Crisby |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
Pathology Homocysteine biology business.industry Vascular disease Clinical Biochemistry General Medicine medicine.disease Biochemistry digestive system diseases Stenosis chemistry.chemical_compound chemistry Internal medicine medicine.artery Methylenetetrahydrofolate reductase Genotype medicine Cardiology biology.protein Vitamin B12 Internal carotid artery business Stroke |
| Zdroj: | European Journal of Clinical Investigation. 28:285-289 |
| ISSN: | 0014-2972 |
| DOI: | 10.1046/j.1365-2362.1998.00281.x |
| Popis: | Methods A biallelic polymorphism of the methylenetretrahydrofolate reductase (MTHFR) gene, reported to influence the plasma level of homocysteine (Hcy), was investigated for a possible role in influencing the risk of ischaemic cerebrovascular disease (ICVD) and occlusive atherosclerosis in 126 patients with ischaemic stroke and 70 patients with internal carotid artery (ICA) stenosis. Results Only minor differences were observed between different groups of patients and control subjects. Although 47% of ICA stenosis patients had increased plasma Hcy, the MTHFR genotype did not correlate with levels of either Hcy, folic acid or vitamin B12. In addition, the MTHFR genotype did not affect Hcy levels, even in the presence of low blood folate. Conclusion We conclude that this common MTHFR gene polymorphism does not exert a significant influence on the risk of developing ICVD or ICA stenosis, and does not cause the increased level of Hcy observed in ICA stenosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|