18F-choline PET/4D CT in hyperparathyroidism: correlation between biochemical data and study parameters

Autor: Luis Boccalatte, A.M. Galich, Natalia Lucía Gómez, Martina Musumeci, Carlos Collaud, Marcelo Figari
Rok vydání: 2020
Předmět:
Zdroj: Revista Española de Medicina Nuclear e Imagen Molecular (English Edition). 39:273-278
ISSN: 2253-8089
Popis: Background Hyperparathyroidism (PTH) is characterised by increased levels of parathyroid hormone (PTH), surgical excision being the only definitive curative option. After establishing the need for surgery, it is essential to identify the parathyroid glands in the preoperative period to use a minimally invasive approach. Negativity and / or discrepancy in first- line studies (ultrasound and Tc-99 m MIBI parathyroid scintigraphy) require more accurate images to reduce the likelihood of bilateral cervical exploration or reintervention. Objectives a) To demonstrate the sensitivity of 18 F-fluorocholine (18 F-choline) positron emission tomography (PET)/4D computed tomography (4D CT) in HPT. b) To check whether there is a correlation between calcaemia and preoperative PTH versus size and early and late SUVmax (Standardized Uptake Value) of the gland, determined by 18 F-choline PET/4D CT and c) to study the behaviour of parathyroid lesions with intravenous contrast (IV). Material and methods A total of 28 patients were included between 2016 and 2019 in a single institution. Prospective observational cohort study. Correlations were analysed using Pearson's coefficient for variables with normal distribution and Spearman (rho) for those with non-normal distribution. Anatomopathological analysis was the benchmark standard to determine sensitivity was. A p Results Of the 28 patients who underwent 18 F-choline PET/4D CT, 18 were operated. Of the 26 lesions diagnosed by 18 F-choline PET/4D CT as suggestive of parathyroid lesions, 23 corresponded to glandular disease (adenoma or hyperplasia) establishing a sensitivity of 88.5%. There was a correlation between the patient's preoperative PTH and the maximum size of the gland on 18 F-choline PET/4DCT. (Spearman .66; p = .0014). The parathyroid lesions showed, in addition to IV contrast enhancement, distinctive behavioural characteristics identified as highly suggestive. Conclusions 18 F-choline PET/CT 4D is an anatomical and functional study with high sensitivity in patients with HPT with negative or discrepant first-line studies. Preoperative PTH showed a correlation with maximum gland size on 18 F-choline PET/CT 4D. Parathyroid lesions behave in a highly suggestive way and are enhanced by IV contrast.
Databáze: OpenAIRE
Externí odkaz: