Practical Synthetic Method for Ogipeptin Derivatives
| Autor: | Shingo Takiguchi, Takahide Nishi |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Synlett. 34:277-282 |
| ISSN: | 1437-2096 0936-5214 |
| Popis: | In synthesizing novel derivatives of the natural cyclic peptides the ogipeptins, we established a simple and practical solid-phase peptide synthesis and macrocyclization method. By using this method, it became possible to obtain skeleton-modified ogipeptin derivatives with dehydroxylation of the β-hydroxy-α,γ-diaminobutyric acid, replacement of the (Z)-dehydrobutyrine residue, or replacement of the arginine residue. |
| Databáze: | OpenAIRE |
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