| Autor: |
Jaume Padilla, John P. Thyfault, Nathan T. Jenkins, M. Harold Laughlin, Jacqueline M. Crissey, Jeffrey S. Martin, R. Scott Rector |
| Rok vydání: |
2013 |
| Předmět: |
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| Zdroj: |
Experimental Physiology. 99:262-271 |
| ISSN: |
0958-0670 |
| DOI: |
10.1113/expphysiol.2013.074047 |
| Popis: |
Thevascularactionsofinsulinarecomplex,becauseitcanstimulatebothnitricoxide-mediated dilatation and endothelin (ET)-1-mediated constriction. We examined vasoreactivity to insulin in isolated feed arteries of the gastrocnemius (GFA) and soleus muscles (SFA) of 32-week-old Long‐EvansTokushimaOtsuka(LETO)andOtsukaLong‐EvansTokushimafatty(OLETF)rats, ahyperphagicrodentmodelofobesityandinsulinresistance.Theinsulin-inducedvasoreactivity of SFA and GFA was similar in LETO (healthy) and OLETF (obese/insulin-resistant) rats. However, examination of between-vessel effects revealed a number of novel insights into the heterogeneous vascular effects of insulin. Soleus feed arteries dilated more than GFA in LETO at 100 and 1000 μIU ml −1 insulin (23 versus 6a nd 28versus 0%, respectively; P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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