| Autor: |
Connie Fung, Lisa M. Fraser, Gabriel M. Barrón, Matthew B. Gologorsky, Samantha N. Atkinson, Elias R. Gerrick, Michael Hayward, Jennifer Ziegelbauer, Jessica A. Li, Katherine F. Nico, Miles D.W. Tyner, Leila B. DeSchepper, Amy Pan, Nita H. Salzman, Michael R. Howitt |
| Rok vydání: |
2022 |
| DOI: |
10.1101/2022.10.24.512770 |
| Popis: |
Succinate produced by the commensal protistTritrichomonas musculis(T. mu) stimulates chemosensory tuft cells, resulting in intestinal type 2 immunity. Tuft cells express the succinate receptor SUCNR1, yet this receptor does not mediate anti-helminth immunity nor alter protist colonization. Here, we report that microbial-derived succinate increases Paneth cell numbers and profoundly alters the antimicrobial peptide (AMP) landscape in the small intestine. Succinate was sufficient to drive this epithelial remodeling, but not in mice lacking tuft cell chemosensory components required to detect this metabolite. Tuft cells respond to succinate by stimulating type 2 immunity, leading to interleukin-13-mediated epithelial and AMP expression changes. Moreover, type 2 immunity decreases the total number of mucosa-associated bacteria and alters the small intestinal microbiota composition. These findings demonstrate that a single metabolite produced by commensals, likeT. mu, can markedly shift the intestinal AMP profile and suggest that tuft cells utilize SUCNR1 to modulate bacterial homeostasis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
