Comparison of Sinusoidal Obstruction Syndrome in Gastric Cancer Patients Receiving S-1/oxaliplatin Versus Capecitabine/oxaliplatin
| Autor: | Eo Jin Kim, Sook Ryun Park, Min Ju Kim, Moonho Kim, Seyoung Seo, Mi-Jung Kim |
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| Rok vydání: | 2021 |
| Předmět: |
endocrine system
Cancer Research medicine.medical_specialty Chemotherapy urogenital system business.industry Capecitabine/oxaliplatin medicine.medical_treatment Cancer General Medicine medicine.disease Gastroenterology Oxaliplatin Discontinuation Capecitabine Oncology Recovery rate Internal medicine embryonic structures Medicine Clinical significance business medicine.drug |
| Zdroj: | Anticancer Research. 41:391-402 |
| ISSN: | 1791-7530 0250-7005 |
| DOI: | 10.21873/anticanres.14788 |
| Popis: | Background/aim Oxaliplatin-based chemotherapy is associated with hepatic sinusoidal obstruction syndrome (SOS). Patients and methods We analyzed patients from two prospective trials, in which capecitabine/oxaliplatin (XELOX, 8 cycles; n=51) and S-1/oxaliplatin [SOX, continuous (SOX-C, n=50), or intermittent (discontinuation after cycle 6 and restart on progression, SOX-I, n=50)] were administered. We compared severity (splenomegaly, thrombocytopenia, liver enzyme levels, and hepatic parenchymal heterogeneity), clinical significance (delay or dose-reduction of chemotherapy), and reversibility of SOS (splenomegaly and thrombocytopenia after stopping chemotherapy) between SOX and XELOX in gastric cancer patients. Results SOX was more likely to be associated with splenomegaly, thrombocytopenia, hyperbilirubinemia, and hepatic parenchymal heterogeneity than XELOX. Splenomegaly was partially reversible after stopping chemotherapy in both regimens, but recovery rate was lower in SOX. Proportion of delayed or dose-reduced chemotherapy cycles due to thrombocytopenia was significantly higher in SOX-C than in XELOX. Conclusion S-1 combination is more likely to worsen oxaliplatin-induced hepatic sinusoidal injuries than capecitabine in gastric cancer patients. |
| Databáze: | OpenAIRE |
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