Acetaminophen Induced Hepatic Toxicity: Protective Role of Ageratum conyzoides
| Autor: | Edet Okon Akpanyung, S. O. Ita, B. I. Umoh, S. O. Ukafia, E. E. Ben |
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| Rok vydání: | 2009 |
| Předmět: |
Nutrition and Dietetics
Ethanol biology Ageratum conyzoides digestive oral and skin physiology Public Health Environmental and Occupational Health Pharmacology biology.organism_classification digestive system digestive system diseases Hepatic toxicity Enzyme assay Acetaminophen Toxicology chemistry.chemical_compound chemistry Toxicity medicine biology.protein Alanine aminotransferase Caffeine Food Science medicine.drug |
| Zdroj: | Pakistan Journal of Nutrition. 8:928-932 |
| ISSN: | 1680-5194 |
| DOI: | 10.3923/pjn.2009.928.932 |
| Popis: | The preventive potentials of ethanol leaf extract of Ageratum conyzoides (ACE) against acute acetaminophen and caffeinated acetaminophen over dose in Wister rats were investigated. Thirty Wister rats of both sexes were divided into 6 groups of 5 rats per group. There were two control groups. Animals in control group 1 were administered 600 mg/kg body weight of acetaminophen intraperitoneally (ip) whereas, animals in control group 2 in addition to acetaminophen were administered 100 mg/kg body weight of caffeine by oral gavage. Experimental groups 3 and 4 were treated with acetaminophen as in group 1 but in addition received 250 and 500 mg/kg body weight, respectively of ACE by oral gavage, The experimental groups 5 and 6 were treated as in control group 2 and in addition received 250 and 500 mg/kg body weight, respectively of ACE. The treatment lasted 14 days. Serum Aspartate Aminotransferase (AST) and Alanine aminotransferase (ALP) levels (U/L) significantly increased (p |
| Databáze: | OpenAIRE |
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