A novel dairy-derived isolate that inhibits adipogenesis and significantly reduces weight gain in a high fat animal model

Autor:	Janu Dhulia, Dominic J. Autelitano, Christopher G. Hosking, Antonio Rajic
Rok vydání:	2010
Předmět:	medicine.medical_specialty Whey protein Adiponectin Insulin medicine.medical_treatment Leptin Adipokine Biology Applied Microbiology and Biotechnology chemistry.chemical_compound Endocrinology chemistry Adipogenesis Adipocyte Internal medicine medicine medicine.symptom Weight gain Food Science
Zdroj:	International Dairy Journal. 20:480-486
ISSN:	0958-6946
DOI:	10.1016/j.idairyj.2010.02.002
Popis:	A novel, highly enriched bioactive bovine whey protein fraction (LAP001) was shown to directly inhibit adipocyte differentiation and lipid accumulation over a wide concentration range. Further in vitro characterisation showed that LAP001 suppressed induction of PPARγ expression in a dose-dependent manner. Administration of LAP001 to rats maintained on a high-fat diet over a 28-day period led to a significant reduction in weight gain and prevented a rise in plasma glucose concentration without significantly affecting plasma insulin concentrations. In additional, there was a beneficial modulation of major serum adipokines (decreased leptin and increased adiponectin concentration) that impact on metabolic parameters related to obesity. As such, LAP001 represents a novel and potentially attractive dairy-derived fraction for further development and testing as an agent that can inhibit weight gain, and aid in the control of obesity-related metabolic disorders.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f4004bcbd8f783864857b8a6545c1fc4 https://doi.org/10.1016/j.idairyj.2010.02.002 Zobrazit plný text záznamu Full Text from ScienceDirect