Characterization of Occult Hepatitis B Virus Infection Among Iranian Patients with Behcet's Disease; Correlation with Clinical Status
| Autor: | Mehdi Norouzi, Maassoumeh Akhlaghi, Shaya Mostafaei, Seyedeh Tahereh Faezi, Shahram Barfi, Seyed Mohammad Jazayeri, Saied Ghorbani, Zohreh Jadali, Seyed Moayed Alavian, Vahdat Poortahmasebi, Vahideh Imeni, Mahdi Mahmoudi, Farhad Shahram, Seyed Hamidreza Monavari |
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| Rok vydání: | 2021 |
| Předmět: |
030203 arthritis & rheumatology
Hepatitis B virus medicine.medical_specialty HBsAg Hepatology business.industry Disease Behcet's disease medicine.disease_cause medicine.disease Serology 03 medical and health sciences 0302 clinical medicine Infectious Diseases Internal medicine medicine Etiology 030211 gastroenterology & hepatology business Vasculitis Viral load |
| Zdroj: | Hepatitis Monthly. 21 |
| ISSN: | 1735-3408 1735-143X |
| Popis: | Background: Behcet's disease (BD) is a chronic multisystem vasculitis with an unknown etiology. During the past years, several reports are published on the occult hepatitis B infection (OBI), the presence of hepatitis B virus (HBV) DNA in the absence of HBsAg, in rheumatic diseases. Objectives: The current study aimed to, firstly, investigate the prevalence of OBI in patients with BD, and, secondly, its potential association with the clinical and therapeutic status of BD. Methods: HBV serological markers and HBV DNA were evaluated in 220 consecutive BD patients to detect OBI. Demographic and clinical data of OBI positive and negative groups were compared. Results: The mean age of patients was 39.24 (± 10.57), and 134 (62.9%) were male. The mean disease duration was 14.13 (± 8.63) years. No HBsAg positive case was found, but HBV DNA was found in 19 (8.6%) patients. The median viral load value was 475.84 copy/mL. We compared clinical data of 10 OBI positive and 156 OBI negative BD patients with complete and accessible data. There was no difference between the two groups concerning demographic characteristics (age, sex, and disease duration), different clinical manifestations, or types of medications (immunomodulatory, cytotoxic, and corticosteroids). Conclusions: This is the first study showing a rather high prevalence of OBI among BD patients. We did not find any correlation between OBI positivity and different clinical manifestations, medications, or HLA-B51. Further studies are needed on a larger group of patients and by molecular HBV evaluation (as well as serologic) regarding this possible association. |
| Databáze: | OpenAIRE |
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