Development of Novel Scaffolds for Tissue Engineering by Flock Technology
| Autor: | Birgit Mrozik, Wiltrud Richter, Helge Bertram, Anne Bernhardt, Michael Gelinsky, Anja Walther, Chokri Cherif, Wolfgang Pompe, Gerald Hoffmann, Gerhilt Dr. Schmack |
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| Rok vydání: | 2007 |
| Předmět: |
010302 applied physics
Scaffold Materials science Polymers and Plastics Biomaterial Nanotechnology 02 engineering and technology 021001 nanoscience & nanotechnology 01 natural sciences Compressive strength Tissue engineering 0103 physical sciences Chemical Engineering (miscellaneous) Adhesive Flock 0210 nano-technology Flocking (texture) Biomedical engineering |
| Zdroj: | Textile Research Journal. 77:892-899 |
| ISSN: | 1746-7748 0040-5175 |
| DOI: | 10.1177/0040517507081283 |
| Popis: | Flock technology is a method well known in the textile industry. Short fibers are applied almost vertically on a substrate, coated with a flocking adhesive. Until now, this technology has not been used in the field of biomaterials. Our aim was to use electrostatic flocking for fabricating a novel type of scaffolds for tissue engineering. This method offers the possibility to create matrices with anisotropic properties that have a high compressive strength despite high porosity. First, experiments were performed using a membrane made of mineralized collagen as substrate, gelatine as adhesive and polyamide flock fibers. Different kinds of cells were cultured in the scaffolds for up to six weeks. Using microscopic methods and biochemical analyses, we could demonstrate that cells adhered and proliferated well in this new type of scaffold. Therefore, we can summarize that flocking is a technology suitable for fabrication of scaffolds for cell cultivation and tissue engineering. |
| Databáze: | OpenAIRE |
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