Iatrogenes Cushing-Syndrom und Mutatio tarda durch Dexamethason-haltige Nasentropfen
| Autor: | E. Keller, R. Täschner, H. Wetzig, Michael Fuchs, F. Kertscher |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
medicine.medical_specialty
Chemotherapy medicine.drug_class business.industry medicine.medical_treatment medicine.disease Gastroenterology Surgery Cushing syndrome medicine.anatomical_structure Otorhinolaryngology Internal medicine otorhinolaryngologic diseases medicine Corticosteroid Endocrine system Nasal administration business Nose Dexamethasone Hydrocortisone medicine.drug |
| Zdroj: | HNO. 47:647-650 |
| ISSN: | 1433-0458 0017-6192 |
| DOI: | 10.1007/s001060050439 |
| Popis: | Nasal steroid drops can produce iatrogenic Cushing's syndrome if the recommended dose is exceeded. We now report a 19-year-old male patient for whom dexamethasone nasal drops were prescribed because of nasal obstruction. He had been using these drops for more than 5 years, with a daily dexamethasone dose of 0.7-1.0 mg. It is likely that significant amounts of dexamethasone were swallowed and absorbed by the patient's gastrointestinal tract. As a consequence, the patient developed Cushing's syndrome with panhypopituitarism, growth retardation, osteoporosis and hypertension. A boyish size of the larynx resulted in a fundamental speaking frequency of a child. After discontinuing the intranasal use of the of dexamethasone and adjusting doses of hydrocortisone over 3.5 months a normalization of endocrine function occurred with the beginning of puberty and normal sexual changes. These findings show that the use of nasal steroid drops particularly in children should be limited to a short period and drugs with a low absorption dose employed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink