ChemInform Abstract: Antimalarial Activity of Parthenin and Its Derivatives

Autor:	S. N. Kulkarni, G. C. Kirby, B. A. Nagasampagi, M. J. O'Neill, S. R. Rojatkar, David C. Warhurst, J. D. Phillipson, M. M. Kulkarni, M. Hooper
Rok vydání:	2010
Předmět:	Terpene Oxygen atom biology Chemistry Resistant strain Amphiphile Molecule Plasmodium falciparum General Medicine biology.organism_classification Combinatorial chemistry
Zdroj:	ChemInform. 22
ISSN:	0931-7597
Popis:	Parthenin and some of its derivatives have been shown to possess significant anti-malarial activity against a multi-drug resistant strain of Plasmodium falciparum. Structure-activity relationships in this series of compounds are discussed and possible mechanisms of action considered. Molecular matching of the oxygen atoms of parthenin and the new anti-malarial drug qinghaosu shows both molecules to be amphipathic with common areas for their oxygen atoms and hydrocarbon frameworks.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f3f01a3095b3616faa86b5eb5d3e7c44 https://doi.org/10.1002/chin.199115246 Zobrazit plný text záznamu Plný text