Compensatory depression of arterial pressure and reversal of ECG abnormalities by Annona muricata and Curcuma longa in hypertensive Wistar rats
| Autor: | Olayinka A. Oridupa, Victor Oluwaseun Adegboye, Olumuyiwa Abiola Adejumobi, Bukola Adedayo Abegunde, Ademola Adetokunbo Oyagbemi, Folusho Bolawaye Falade, Ayobami Deborah Obisesan, Temidayo Olutayo Omobowale, Precious Chima Ekwem |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Proteinuria
Urobilinogen biology Urinalysis medicine.diagnostic_test business.industry Lisinopril Physiology 030204 cardiovascular system & hematology biology.organism_classification medicine.disease 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Blood pressure Hydrochlorothiazide Complementary and alternative medicine chemistry medicine Ketonuria medicine.symptom business Annona muricata 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Journal of Complementary and Integrative Medicine. 19:375-382 |
| ISSN: | 1553-3840 2194-6329 |
| DOI: | 10.1515/jcim-2020-0280 |
| Popis: | Objectives Increasing hypertension incidence in Sub-Sahara Africa and the current cost of management of the metabolic disorder has necessitated research on medicinal plants employed in African Traditional Medicine for hypertension. Thus, this study evaluated antihypertensive effect of Annona muricata leaves or Curcuma longa rhizomes in experimentally-induced hypertensive male Wistar rats (n=70) which were unilaterally nephrectomized and daily loaded with 1% salt. Cardiovascular and haematological changes, as well as urinalysis were determined. Methods Rats were uninephrectomized and NaCl (1%) included in drinking water for 42 days. Extract-treated hypertensive rats were compared to normotensive, untreated hypertensive and hypertensive rats treated with lisinopril (5 mg/70 kg) or hydrochlorothiazide (12.5 mg/70 kg). A. muricata extract or C. longa extract were administered at 100, 200 or 400 mg/kg. Blood pressure (systolic, diastolic and mean arterial) and electrocardiogram was measured on day 41. Twenty-four-hour urine samples were collected from day 42. Blood samples were collected on day 43 for haematology (PCV, red cell indices, WBC and its differentials, and platelets). Results A. muricata or C. longa extracts caused a decline in elevated blood pressure of hypertensive rats. Heart rate and QT segment reduction coupled with prolonged QRS duration were reversed in extract-treated rats, with significant increases in hemogram parameters indicating increased blood viscosity. Also, leukocyturia, proteinuria and ketonuria with increased urine alkalinity, urobilinogen and specific gravity which are classical indicators of poor prognostic outcomes in hypertension were reversed in extract-treated rats. Conclusions In conclusion, A. muricata and C. longa have cardioprotective effect with reversal of derangements in haemogram and urinalysis associated with hypertension. |
| Databáze: | OpenAIRE |
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