1,1-Dianisyl-2,2,2-trichloroethyl ethers — A new protection for the hydroxyl group

Autor:	S. Lehnhoff, Ivar Ugi, Rosa Maria Karl, Roland Klösel, Stephan König
Rok vydání:	1995
Předmět:	Chemistry Group (periodic table) Organic Chemistry Drug Discovery Organic chemistry Moiety Alkylation Biochemistry Vicinal
Zdroj:	Tetrahedron. 51:3759-3766
ISSN:	0040-4020
DOI:	10.1016/0040-4020(95)00120-w
Popis:	β-Haloalkyl protecting groups are well established However, there was a lack of an appropriate protection, especially for carboxyl and vicinal hydroxyl groups. This problem was now solved by design of the 1,1-dianisyl-2,2,2-trichloroethyl group (DATE). The alkylation of model alcohols with the DATE moiety is described The resulting β-haloallryl ethers proved to be remarkable stable against acids and bases. Deblocldng of the model alcohols is achieved in high yields.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f3eae7670d1a0d0a97a6d975729c7a6b https://doi.org/10.1016/0040-4020(95)00120-w Zobrazit plný text záznamu Full Text from ScienceDirect