Benzothiazolylthio carbapenems: potent anti-MRSA agents
| Autor: | Jon G. Sundelof, Earl St. Rose, Kenneth J. Wildonger, Karen Dorso, Timothy A. Blizzard, Sandra P. Szumiloski, Ronald W. Ratcliffe, Sherman T. Waddell, Joyce Kohler, Joann Huber, Robert R. Wilkening, Gail G. Hammond |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Chemistry
Organic Chemistry Clinical Biochemistry Pharmaceutical Science biochemical phenomena metabolism and nutrition Anti mrsa bacterial infections and mycoses medicine.disease_cause Biochemistry Combinatorial chemistry Staphylococcus aureus Drug Discovery medicine Molecular Medicine Pharmacophore Molecular Biology |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 5:1427-1432 |
| ISSN: | 0960-894X |
| Popis: | A series of sulfur-linked benzothiazolyl carbapenems has been prepared and evaluated against a battery of microorganisms. Many of the compounds displayed good activity against methicillin-resistant Staphylococcus aureus (MRSA). Data is presented which delimits the pharmacophore and provides a preliminary SAR. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect