Study of the effectiveness of megestrol acetate application for suppressing estral cycle in cats
| Autor: | S. А. Sapko |
|---|---|
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | VETERINARY SCIENCE, TECHNOLOGIES OF ANIMAL HUSBANDRY AND NATURE MANAGEMENT. :66-70 |
| ISSN: | 2663-5542 2617-8346 |
| Popis: | A study on the effectiveness of megestrol acetate to suppress the estral cycle in cats using the drug "Sexstop" was carried out. Conducted studies of the effectiveness of the "Sexstop" in the drug form of tablets and suspension containing megestrol acetate in 1 tablet - 5 mg and 1 ml - 20 mg, respectively was established. Experimental groups of cats that obtained oral megastroly acetate preparations, the FSH concentration in serum increased compared to baseline levels of 0.6 ng / ml, however, only to 1.2- 1.3 ng / ml, which by 46,15% less than in control animals, and this concentration of the hormone was not sufficient for the transition to the phase of the estrus from the proestrus, which is confirmed by the results of the ultrasound. On 8-9th day from the first signs of proestrus in cats of experimental groups, the concentration of FSH again decreases to the basal level as well as in the control animals that did not receive the drug. An ester cycle in cats of the first and second groups was restored 3-4 months after the administration of the drug. This fact, because megestrol acetate, metabolised for 8 days and is excreted from the body and in cats gradually resurrected estral cycle. It has been established that the active ingredient of megestrol acetate ("Sexstop" in the form of tablets and suspension) inhibits the synthesis and release of the follicle-stimulating hormone, which leads to inhibition of folliculogenesis, and, accordingly, the synthesis of estradiol, which makes it impossible for the manifestation of sexual cycling. |
| Databáze: | OpenAIRE |
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