Timing of detection of anencephaly in The Netherlands

Autor:	K. van de Kamp, Eva Pajkrt, L. van Leijden, R. J. M. Snijders, Caterina M. Bilardo, J. H. Fleurke-Rozema
Rok vydání:	2015
Předmět:	medicine.medical_specialty Pregnancy Fetus business.industry Obstetrics Obstetrics and Gynecology Gestational age Prenatal diagnosis medicine.disease Nuchal Translucency Measurement Anencephaly Sonographer Medicine Gestation business Genetics (clinical)
Zdroj:	Prenatal Diagnosis. 35:483-485
ISSN:	0197-3851
Popis:	ObjectiveThe objective of this study is to assess the gestational age at detection and prevalence of anencephaly in the North of The Netherlands over a 5-year period. MethodsA case list of all cases of anencephaly from two fetal medicine units was compiled. Cases were included if the estimated due date was between 1 August 2008 and 31 July 2013. ResultsOverall prevalence of anencephaly was 5.4 per 10.000 pregnancies (n=110). The majority of cases (69%) was detected before 18 weeks' gestation. Factors determining successful early diagnosis were competence level of the sonographers, with a significantly higher detection rate when scans were performed by a sonographer licensed by the Fetal Medicine Foundation (FMF) for nuchal translucency measurement (p=0.001), and gestational age at or beyond 11weeks of gestation (p=0.024). ConclusionImproving detection of anencephaly in the first trimester requires ultrasound screening at or after 11weeks of gestation, performed by experienced sonographers trained in recognizing fetal anomalies. Sonographers should be instructed that the goal of the first trimester scan is not only to measure nuchal translucency thickness but also to exclude major anomalies. (c) 2015 John Wiley & Sons, Ltd.
Databáze:	OpenAIRE
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