Synthesis and Antiviral Activity of Glycyrrhizic-Acid Conjugates with Aromatic Amino Acids
| Autor: | L. A. Baltina, A. I. Fairushina, M. Yu. Eropkin, N. I. Konovalova, P. A. Petrova, E. M. Eropkina |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification 010405 organic chemistry Stereochemistry viruses Tryptophan Glycoside Phenylalanine Plant Science General Chemistry medicine.disease_cause 01 natural sciences General Biochemistry Genetics and Molecular Biology Virus 0104 chemical sciences Amino acid 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology Herpes simplex virus chemistry medicine Aromatic amino acids Tyrosine |
| Zdroj: | Chemistry of Natural Compounds. 53:1096-1100 |
| ISSN: | 1573-8388 0009-3130 |
| DOI: | 10.1007/s10600-017-2209-7 |
| Popis: | Amino-acid conjugates of glycyrrhizic acid (GA) containing phenylalanine, tyrosine, and tryptophan in the carbohydrate and triterpene parts were synthesized using N-hydroxybenzotriazole (HOBt)-N,N′-dicyclohexylcarbodiimide (DCC) and sodium salts of the amino acids. GA conjugates containing two aminoacid residues in the glycoside carbohydrate part were synthesized using N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline. The GA conjugate with tyrosine exhibited weak but consistent antiviral activity against flu virus A/St.-Petersburg/05/09 (H1N1)pdm09 that was similar to the standard strain A/California/07/09 and pronounced antiviral activity against respiratory-syncytial virus (RSV) and herpes simplex virus (HSV-1). |
| Databáze: | OpenAIRE |
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