MicroRNAs: Multifaceted Regulators of Colorectal Cancer Metastasis and Clinical Applications
Autor: | Xian-Ling Qian, Xiang-Qiong Wen, Jiaping Hu, Tai-Yuan Li, Wei-Quan Zhu, Huan-Kui Sun, Lin-Lin Zheng |
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Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Angiogenesis Colorectal cancer Mechanism (biology) Cancer Biology medicine.disease digestive system diseases Metastasis 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Oncology 030220 oncology & carcinogenesis microRNA medicine Cancer research Pharmacology (medical) Anoikis Signal transduction |
Zdroj: | OncoTargets and Therapy. 13:10851-10866 |
ISSN: | 1178-6930 |
Popis: | Colorectal cancer (CRC) is the third-commonest malignant cancer, and its metastasis is the major reason for cancer-related death. The process of metastasis is highly coordinated and involves a complex cascade of multiple steps. In recent years, miRNAs, as highly conserved, endogenous, noncoding, single-stranded RNA, has been confirmed to be involved in the development of various cancers. Considering that miRNA is also involved in a series of biological behaviors, regulating CRC occurrence and development, we review and summarize the role of miRNAs and related signaling pathways in several CRC-metastasis stages, including invasion and migration, mobility, metabolism, epithelial-mesenchymal transition, tumor-microenvironment communication, angiogenesis, anoikis, premetastatic-niche formation, and cancer stemness. In addition, we review the application of miRNAs as diagnostic CRC markers and in clinical treatment resistance. This review can contribute to understanding of the mechanism of miRNAs in CRC progression and provide a theoretical basis for clinical CRC treatment. |
Databáze: | OpenAIRE |
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