A novel synthesis of 3(R)-HETE, 3(R)-HTDE and enzymatic synthesis of 3(R),15(S)-DiHETE

Autor:	Igor Ivanov, Natalia V Groza, Stepan G. Romanov, Galina I. Myagkova, Santosh Nigam
Rok vydání:	2002
Předmět:	Chemistry Stereochemistry Organic Chemistry Drug Discovery Polymer chemistry Substrate (chemistry) Total synthesis Enzymatic synthesis Triple bond Biochemistry Coupling reaction Catalytic hydrogenation Catalysis
Zdroj:	Tetrahedron. 58:9859-9863
ISSN:	0040-4020
DOI:	10.1016/s0040-4020(02)01289-9
Popis:	3(R)-HETE and 3(R)-HTDE were prepared by cross-coupling of methyl 3(R)-hydroxyhex-5-ynoate either with 1-bromo-2,5,8-tetradecatriyne or 1-bromo-2-octyne followed by catalytic hydrogenation of the skipped triple bonds formed using Lindlar's catalyst. Enzymatic synthesis of 3(R),15(S)-DiHETE was accomplished by soybean LOX-1 using 3(R)-HETE as a substrate.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f3d06cbfb3e95a013f612c7e2c2363d7 https://doi.org/10.1016/s0040-4020(02)01289-9 Zobrazit plný text záznamu Full Text from ScienceDirect