| Popis: |
Fresh undried winter leaves of Azadirachta indica were fed with [2-14C, 4R-3H1] MVA. Atomic and isotopic ratios in nimocinol & nimocinolide, thus isolated showed the loss of one 14C from the side chain and four tritium atoms - one from side chain and three from apotetracyclic triterpene skeleton. The biosynthetic pathway thus established suggested the involvement of euphol (Δ8,9 compound) which is isomerised to butyrospermol (Δ7,8 compound) followed by an apo-rearrangement during which one methyl migrates from C-14 to C-8 and double bond from C-7 to C-14. |
