IMPAIRMENT OF THE PITUITARY-ADRENAL AXIS FOLLOWING PROLONGED THERAPY WITH CORTICOTROPHIN

Autor:	M. J. Levell, S. R. Stitch, M. J. Noronha
Rok vydání:	1970
Předmět:	endocrine system medicine.medical_specialty Endocrinology Text mining business.industry Endocrinology Diabetes and Metabolism Internal medicine Medicine General Medicine business hormones hormone substitutes and hormone antagonists
Zdroj:	Acta Endocrinologica. 65:608-616
ISSN:	1479-683X 0804-4643
DOI:	10.1530/acta.0.0650608
Popis:	Pituitary-adrenal function was tested in a group of 33 patients with multiple sclerosis who had been treated with corticotrophin for at least 1 year. Assessment was made by measuring the change in the plasma 11-hydroxycorticosteroid concentration following lysine vasopressin (LVP) administration. Ten patients showed abnormally small increases after LVP. Two of the 5 patients with the smallest increases still showed impairment 8 months later. The patients with no withdrawal symptoms had normal or nearly normal increases following LVP. There was an association between the concentration of 11-hydroxycorticosteroids immediately after withdrawal of ACTH and the subsequent response to LVP.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f3c9383077ea8b0303b950616d1c2a03 https://doi.org/10.1530/acta.0.0650608 Zobrazit plný text záznamu