Presence of a platelet aggregating factor in the plasma of patients with thrombotic thrombocytopenic purpura (TTP) and its inhibition by normal plasma
| Autor: | R. Nunez, D.R. Harkness, Eric Chun-Yet Lian, J. J. Byrnes, H. Wallach |
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| Rok vydání: | 1979 |
| Předmět: |
medicine.medical_specialty
Chemistry Immunology Antithrombin Hirudin Thrombotic thrombocytopenic purpura Cell Biology Hematology Heparin medicine.disease Biochemistry In vitro Isoantibodies Purpura Endocrinology hemic and lymphatic diseases Internal medicine medicine Platelet medicine.symptom medicine.drug |
| Zdroj: | Blood. 53:333-338 |
| ISSN: | 1528-0020 0006-4971 |
| DOI: | 10.1182/blood.v53.2.333.bloodjournal532333 |
| Popis: | Three patients with thrombotic thrombocytopenic purpura (TTP) were treated by infusion of normal plasma with dramatic responses. The plasmas collected from these patients during relapse induced in vitro aggregation of washed platelets from both normal donors and the patients during remission. The platelet aggregating factor was not dialyzable or adsorbable by Al(OH)3 and was not inactivated by diisopropylfluorophosphate, hirudin, or heparin in the presence of normal amounts of antithrombin. In contrast to the platelet aggregation induced by platelet isoantibody, the platelet aggregating activity of TTP plasma diminished as a function of time when it was incubated with normal plasma at 37 degrees C. These observations suggest that at least some instances of TTP appear to be due to deficiency of a plasma inhibitor to counteract a platelet aggregating factor demonstrated to be present in the plasma of these patients. |
| Databáze: | OpenAIRE |
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