Two new entries to the ABF tricyclic ring system of 7,17-seco-type C19-diterpenoid alkaloids via free radical cyclization and [3+2] cycloaddition of nitrile oxide

Autor:	Liang Xu, Meng-Chen Liu, Yin-Juan Meng, Yong-Li Li
Rok vydání:	2016
Předmět:	Nitrile 010405 organic chemistry Stereochemistry Chemistry Organic Chemistry Oxide Total synthesis 010402 general chemistry Ring (chemistry) 01 natural sciences Biochemistry Radical cyclization Cycloaddition Terpenoid 0104 chemical sciences chemistry.chemical_compound Intramolecular force Drug Discovery
Zdroj:	Tetrahedron. 72:3171-3176
ISSN:	0040-4020
DOI:	10.1016/j.tet.2016.04.027
Popis:	Two new approaches for the construction the ABF ring systems of 7,17-seco-type C19-diterpenoid alkaloids have been successfully developed by using free radical cyclization and intramolecular nitrile oxide cycloaddition, respectively, as the key steps. Both methods would probably provide alternative strategies for the elaboration of AEF-rings in the total synthesis of 7,17-seco-type C19-diterpenoid alkaloids based on our previously prepared BCD ring systems.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f3c6fa2e4bb4ee3493ac8f46fe027688 https://doi.org/10.1016/j.tet.2016.04.027 Zobrazit plný text záznamu Full Text from ScienceDirect