Nucleolus organizer region heteromorphism in patients with Down syndrome and their parents

Autor:	N. A. Nazmy, S. R. Ismail, S. M. Kotb, M. M. Mokhtar
Rok vydání:	1999
Předmět:	Down syndrome medicine.medical_specialty Obstetrics Significant difference Karyotype General Medicine Biology medicine.disease Modal Number Nondisjunction medicine Etiology In patient Nucleolus organizer region
Zdroj:	Eastern Mediterranean Health Journal. 5:299-306
ISSN:	1687-1634 1020-3397
DOI:	10.26719/1999.5.2.299
Popis:	The study aimed to evaluate the role of nucleolus organizer region [NOR] heteromorphism as an etiological factor for parental nondisjunction in Down syndrome by comparing 25 patients affected by Down syndrome, and their parents with a control group of 80 non-affected Egyptians. All parents had normal karyotypes. The average modal number per parent of Ag-positive NORs was significantly higher in parents than controls. A significant difference in the size of the double-NOR variants [dNORs]was found. The mean maternal and paternal ages were significantly lower, with a significant increase in spontaneous abortions, for dNOR[+] couples compared with dNOR[-] couples
Databáze:	OpenAIRE
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