Opposing Effects of D₁ and D₂ Receptor Activation on Odor Discrimination Learning

Autor:	Christiane Linster, Esther L. Yue, Michelle Pavlis, Thomas A. Cleland
Rok vydání:	2004
Předmět:	Olfactory system Agonist medicine.medical_specialty SCH-23390 Agonist-antagonist medicine.drug_class Dopaminergic Olfaction Behavioral Neuroscience chemistry.chemical_compound Endocrinology Quinpirole chemistry Internal medicine Dopamine receptor D2 medicine Psychology Neuroscience medicine.drug
Zdroj:	Behavioral Neuroscience. 118:184-190
ISSN:	1939-0084 0735-7044
DOI:	10.1037/0735-7044.118.1.184
Popis:	Dopaminergic modulation of cortical activity has been implicated in the formation of reward associations. There is abundant evidence for dopaminergic effects on olfactory processing. Using an olfactory discrimination task, the authors show that D 1 and D 2 dopamine receptors can regulate rats' olfactory discrimination capacities and that the effects of receptor activation functionally oppose one another. Injection of either the D 1 agonist SKF 38393 (10 mg/kg) or the D 2 antagonist spiperone (0.62 mg/kg) facilitated the discrimination of similar odorants but had no effect on the discrimination of dissimilar odorants, whereas both the D, antagonist SCH 23390 (0.025 mg/kg) and the D 2 agonist quinpirole (0.2 mg/kg) significantly impaired rats' ability to discriminate similar and dissimilar odorants.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f3c143e9743534e39cc1201343fda77a https://doi.org/10.1037/0735-7044.118.1.184 Zobrazit plný text záznamu