143. Increased sleep duration is associated with early day elevated salivary alpha-amylase: A potential biomarker for increased sleep drive

Autor: S.J. Gray, Kenneth P. Pitts, Jutta M. Wolf, Nicolas Rohleder
Rok vydání: 2013
Předmět:
Zdroj: Brain, Behavior, and Immunity. 32:e41-e42
ISSN: 0889-1591
Popis: Salivary alpha-amylase (sAA) is associated with sympathetic activation and has recently been posited to be a candidate biomarker for increased sleep drive. This may be because sAA increase indicates a sympathetic arousal offset to increases in sleep drive when alertness is required. This would be observed as associations between increased sAA during alert periods and increased sleep behaviors when arousal is not required. To investigate this question, 45 college aged participants completed a sleep diary for a full week along with psychological and health questionnaires. Additionally, participants provided two days of saliva samples (48 total) which characterized the sAA awakening response (0, +30, +45, & +60 min) and basal levels hourly from 9AM to 8PM. The mean sleep duration for the seven days was 6.6hrs.+1.25. sAA levels were aggregated for each individual from 9AM to 4PM. Z scores for aggregated sAA provided high (>0) and low ( t (45) = 2.158 p = 0.037. Day 2 data indicated similar trend, but were not significant. There were no significant sleep time differences between groups for the week indicating localized association of sAA with sleep time. This finding suggests that sAA increases may indicate efforts to maintain alertness with high sleep drive and may be a candidate biomarker for sleep deprivation.
Databáze: OpenAIRE
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