SARS‐CoV ‐2‐reactive antibody detection after SARS‐CoV ‐2 vaccination in hematopoietic stem cell transplant recipients: Prospective survey from the Spanish Hematopoietic Stem Cell Transplantation and Cell Therapy Group

Autor: Gabriela Sanz-Linares, Anna Sureda, Carlos Solano, Angel Cedillo, Elena Ferrer, Venancio Conesa-Garcia, Lucia Villalon, María Telesa Olave, Carmen Alonso, Blanca Ferrer-Lores, Montserrat Ruiz-García, I Espigado, José Luis Piñana, Ariadna Pérez, Valentín García-Gutiérrez, Ana Saus, Ana Facal-Malvar, Manuel Guerreiro, Lourdes Vázquez, Juan Montoro, Javier López-Jiménez, Jose Angel Hernandez-Rivas, David Navarro, Maria-Jesús Pascual, Lucía López-Corral, Rafael Hernani, Marta Garcia-Blazquez, Juan Luis Muñoz-Bellido, Gabriel Martin-Martin, Beatriz Gago, Rodrigo Martino, Sara Marcos-Corrales, Andrés Sanchez-Salinas
Rok vydání: 2021
Předmět:
Zdroj: American Journal of Hematology. 97:30-42
ISSN: 1096-8652
0361-8609
DOI: 10.1002/ajh.26385
Popis: This is a multicenter prospective observational study which included a large cohort (n = 397) of allogeneic (allo-HSCT) (n = 311) and autologous (ASCT) hematopoietic stem cell transplant (n = 86) recipients who were monitored for antibody detection within 3 to 6 weeks after complete SARS-CoV-2 vaccination from February 1st 2021 to July 20th 2021. Most patients (n = 387, 97.4%) received mRNA-based vaccines. Most of recipients (93%) were vaccinated more than 1 year after transplant. Detectable SARS-CoV-2-reactive antibodies were observed in 242 (78%) of allo-HSCT and in 73 (85%) of ASCT recipients. Multivariate analysis in allo-HSCT recipients identified lymphopenia
Databáze: OpenAIRE
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