| Popis: |
Breast cancer is the most common malignant tumor affecting women, and the most frequent site of distant metastases in this localization is bone. Indeed, 85% of patients who die from breast cancer have bone metastasis (Haagensen, 1956; Ackerman, 1970) and early bone metastasis detection is thus extremely important. While conventional X-ray skeletal surveys are not sensitive enough to detect early bone metastasis, radioisotopic bone scanning has been reported highly sensitive in localizing skeletal metastasis; metastases show up on scans earlier than on X-rays by an average of 4 months (Charkes, 1975; Hoffman, 1972). However, these physical methods only reveal patent lesions. |
