Diagnostic certainty and potential for misclassification in exocrine pancreatic cancer
| Autor: | Miquel Porta, Núria Malats, Josep L. Piñol, Juli Rifà, Montserrat Andreu, Francisco X. Real, null PANKRAS I Project Investigators |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Radical treatment
medicine.medical_specialty Pancreatic disease Epidemiology business.industry media_common.quotation_subject Odds ratio Certainty medicine.disease Surgery Internal medicine medicine Exocrine pancreatic cancer Degree of certainty Information bias business Clinical record media_common |
| Zdroj: | Journal of Clinical Epidemiology. 47:1069-1079 |
| ISSN: | 0895-4356 |
| DOI: | 10.1016/0895-4356(94)90123-6 |
| Popis: | Whereas over the last decade epidemiologic studies on exocrine pancreatic cancer (EPC) continued to show a remarkable heterogeneity in diagnostic criteria applied to define caseness, the actual magnitude and consequences of misclassification remain largely unexplored. The objectives were: (1) to estimate the degree of certainty with which cases of EPC are diagnosed in the two participating hospitals (to this end a diagnostic certainty classification (DCC) was developed; (2) to test whether characteristics of cases differed by degree of diagnostic certainty; and (3) to assess what influence different definitions of case might have on risk estimates for tobacco and alcohol. All cases with a discharge diagnosis of EPC who attended at the Hospital del Mar between 1980–1990 and at the Hospital Son Dureta between 1983–1990 were identified through their respective tumor registries, and their clinical records were reviewed. Only 52% of 140 cases were classified in the group with a higher probability of EPC (group H). Diagnostic certainty appeared somewhat greater among women (age-adjusted odds ratio [OR a ] 1.60, p = 0.18). Group H showed a higher proportion of cases with an interval from first symptom to diagnosis ⩽ 1 month (OR a = 2.38, p p = 0.051). A radical treatment was exclusively attempted in group H ( p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|