Shock and Multiple-Organ Dysfunction after Self-Administration of Salmonella Endotoxin

Autor:	F S Chuidian, R L Danner, H C Kaulbach, A F Suffredini, A M Taveira da Silva, D R Lambert
Rok vydání:	1993
Předmět:	Resuscitation Lipopolysaccharide Septic shock business.industry Organ dysfunction General Medicine medicine.disease Pathogenesis chemistry.chemical_compound chemistry Coagulation Shock (circulatory) Immunology medicine medicine.symptom Bacterial outer membrane business
Zdroj:	New England Journal of Medicine. 328:1457-1460
ISSN:	1533-4406 0028-4793
DOI:	10.1056/nejm199305203282005
Popis:	Endotoxin, a lipopolysaccharide component of the outer membrane of gram-negative bacteria, is involved in the pathogenesis of septic shock, but it is unclear whether endotoxin alone is capable of causing all the manifestations of the septic shock syndrome. In animals, endotoxin causes many of the clinical features1 but produces a low-cardiac-output form of shock that is unlike the hyperdynamic cardiovascular profile of septic shock in humans2,3. In humans, the administration of endotoxin (4 ng per kilogram of body weight) triggers the release of cytokines,4 activates the coagulation and fibrinolytic systems,5,6 and causes a decrease in systemic vascular . . .
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f39f018f9190de370bb54415bdbe46de https://doi.org/10.1056/nejm199305203282005 Zobrazit plný text záznamu