| Autor: |
А.М. Nosovsky, M.A. Skedina, E.N. Antropova, Z.O. Solovieva, А.А. Kovaleva, V.K. Ilyin, M.P. Rykova |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Aerospace and Environmental Medicine. 55:19-24 |
| ISSN: |
0233-528X |
| DOI: |
10.21687/0233-528x-2021-55-5-19-24 |
| Popis: |
The comprehensive investigation of parodontium tissues of the participants in a 120-d isolation study imitating the artificial spacecraft environment was focused on anaerobic microbiota, immunological parameters of the oral liquid and blood flow velocity within the parodentium microcirculation (PMC). Subjects were 6 healthy people (3 males and 3 females) at the age of 29 to 45 years. Parodentium tissues were investigated 14 and 1 day prior to isolation, 3 times in isolation (every 30 days) and on days 1 and 7 after isolation. Qualitative composition of primary pathogens was determined by the polymerase chain reaction (PCR). Concentration of oral immunoglobulins sIgA, IgA, IgМ was measured using the ELISA assay. Blood flow velocity was measured using high-frequency ultrasound Doppler. Our results showed an increase in the immunoglobulins on days 30 and 84 of isolation and subsequent reduction toward the end of the study. The participants were found to be careers of type-1 pathogen Porphyromonas gingivalis and type-2 pathogen Prevotella intermedia. Following isolation, linear indices of the arteriolar blood velocity grew reliably (p < 0.0007); the capillary blood velocity grew by 6.7 % relative to the pre-isolation baseline data. On day 7, capillary perfusion was noted to improve still further. The observed shifts in the local immunity and presence of pathogens point to deterioration of the parodontium defense mechanisms. It appears that activation of inflammatory processes in isolation and confinement remains probable. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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