Diffusely Abnormal White Matter, T2 Burden of Disease, and Brain Volume in Relapsing-Remitting Multiple Sclerosis
| Autor: | Cornelia Laule, Anthony Traboulsee, Yinshan Zhao, David K.B. Li, Vladislav Miropolsky, Irene M. Vavasour, Alexandra T. Vertinsky, Guojun Zhao, G. R. Wayne Moore, Andrew Riddehough |
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| Rok vydání: | 2018 |
| Předmět: |
Burden of disease
medicine.medical_specialty Expanded Disability Status Scale medicine.diagnostic_test business.industry Multiple sclerosis Magnetic resonance imaging medicine.disease 030218 nuclear medicine & medical imaging White matter 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Atrophy Internal medicine Brain size medicine Radiology Nuclear Medicine and imaging Neurology (clinical) Abnormality business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neuroimaging. 29:151-159 |
| ISSN: | 1051-2284 |
| Popis: | Background and purpose Multiple sclerosis (MS) diffusely abnormal white matter (DAWM) is a mildly hyperintense magnetic resonance imaging abnormality distinct from typical lesions. Our goal was to investigate the prevalence and natural history of DAWM in a large cohort (n = 348) of relapsing-remitting MS (RRMS) patients. Methods The presence of DAWM and relationship to changes in T2 burden of disease (BOD), brain volume (brain fractional ratio, BFR), and disability (Expanded Disability Status Scale, EDSS) were investigated at baseline and year 7-8 (long-term follow-up, LTF). Results DAWM was present in 25.3% (88 of 348) of patients at baseline. At LTF, DAWM was unchanged in 69.3% (61 of 88), decreased in 28.4% (25 of 88), and increased in 2.3% (2 of 88) of patients. Baseline BOD and change in BOD did not significantly differ between patients with and without DAWM. DAWM was associated with greater reduction in BFR at LTF (P = .038). DAWM and DAWM change did not predict EDSS or EDSS progression. Conclusions DAWM is present in a quarter of RRMS patients, and rarely increases or develops de novo. DAWM predicts brain atrophy but does not predict physical disability. Because of its posterior periventricular location, further investigation is warranted to evaluate its relationship to other measures of disability, including visual spatial processing and cognitive function. |
| Databáze: | OpenAIRE |
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