| Autor: |
Lennart Harthon, Nils Svedmyr |
| Rok vydání: |
1974 |
| Předmět: |
|
| Zdroj: |
Atherosclerosis. 20:65-68 |
| ISSN: |
0021-9150 |
| DOI: |
10.1016/0021-9150(74)90079-3 |
| Popis: |
Pentaerythritoltetranicotinate (PETN) was administered to 8 healthy male volunteers in a dose of 1 g × 3 for 10 days. There was a gradual and significant reduction of the fasting plasma cholesterol level with about 25 % of the basal values when measured in the morning. The triglyceride level was also reduced; however, more variably, and most pronounced in subjects with an initially high level. The plasma FFA-level or blood glucose was not changed in the morning fasting samples. There was a gradual and significant increase in the total pyridine content of whole blood. The content of free nicotinic acid in plasma increased maximally with about 0.85 μg/ml 60–120 min after the administration of 1 g PETN but was not elevated in the morning samples taken 14 hr after the last dose. It may be concluded that a moderate but prolonged increase of the nicotinic acid content of plasma is as effective to decrease the plasma lipids as nicotinic acid producing high peak values but rapidly decreasing plasma levels. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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