Asymmetric crystallization of bisguanidinobenzene derivatives

Autor:	Kentaro Yamaguchi, Masatoshi Kawahata, Akiko Ogino, Waka Nakanishi, Tsutomu Ishikawa
Rok vydání:	2007
Předmět:	Quantitative Biology::Biomolecules Circular dichroism Chemistry Organic Chemistry Solid-state Physics::Optics Protonation Biochemistry Spectral line law.invention chemistry.chemical_compound Crystallography law Drug Discovery X-ray crystallography Crystallization Guanidine
Zdroj:	Tetrahedron Letters. 48:8526-8530
ISSN:	0040-4039
Popis:	We show that the mono-N-methylated and -ethylated derivatives of the achiral compound bisguanidinobenzene undergo spontaneous asymmetric crystallization into a chiral form with chiral space group P212121. The absolute configurations of the chiral crystals were determined by X-ray crystallography and correlated with circular dichroism (CD) spectra recorded in the solid state. The corresponding protonated and isopropylated derivatives, by contrast, afforded achiral crystals.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f37dc23994e26c3df9e6db18a5550e98 https://doi.org/10.1016/j.tetlet.2007.09.144 Zobrazit plný text záznamu Full Text from ScienceDirect