Effect of absorption enhancers on the permeation of morphine in the isolated rectum of rabbit
| Autor: | Masakazu Hayashibara, Kikuo Iwamoto, Tadanori Itakura, Yasuhiro Kanba, Yoshihiro Katagiri, Kazuhide Mabuchi |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
musculoskeletal diseases
endocrine system Chromatography urogenital system Sodium chemistry.chemical_element Rectum Absorption (skin) Permeation Suppository Pharmacology In vitro medicine.anatomical_structure chemistry embryonic structures Morphine medicine Enhancer reproductive and urinary physiology medicine.drug |
| Zdroj: | Japanese Journal of Hospital Pharmacy. 16:260-268 |
| ISSN: | 2185-9477 0389-9098 |
| DOI: | 10.5649/jjphcs1975.16.260 |
| Popis: | The morphine hydrochloride suppository (MoS) containing sodium caprate (CA-MoS) or.sodium 5-methoxysalicylate (MS-MoS) was studied physicochemically and biopharmaceutically.The hardness and melting point of such suppository freshly prepared or stored for 4 weeks were not affected by the absorption enhancers on comparison with those of MoS.The release of morphine from CA-MoS was much slower than that from MoS or MS-MoS.In the absorption experiments in vitro using the isolated rectal preparation of rabbit, percent of drug amount that was absorbed (i.e.accumulated in the tissue and permeated) after the application of MoS, CA-MoS and MS-MoS was 61.7, 63.1, and 86.5%, respectively. The rectal transport of morphine in vitro was significantly enhanced in the presence of sodium 5-methoxysalicylate. No histological change was observed in mucosal tissue of the rectum exposed to these absorption enhancers. |
| Databáze: | OpenAIRE |
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