Synthesis of chiral α-acetylenic cyclic amines from α-amino acids: Applications to differentially constrained oxotremorine analogues as muscarinic agents

Autor:	James T. Wasicak, John Y. L. Chung
Rok vydání:	1990
Předmět:	chemistry.chemical_classification Tertiary amine Chemistry medicine.drug_class Stereochemistry Metabolite Organic Chemistry Carboxamide Biochemistry Aldehyde Amino acid chemistry.chemical_compound Drug Discovery Lactam Oxotremorine medicine Muscarinic Agents medicine.drug
Zdroj:	Tetrahedron Letters. 31:3957-3960
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(00)94471-x
Popis:	Application of the Corey-Fuchs reaction on Boc-prolinal, Boc-4-hydroxyprolinal, Bocpiperidinal and Boc-serinal derivatives to give chiral 2-pyrrolidinyl-, 2-piperidinyl- and 4-oxazolidinyl-acetylene derivatives provided rapid access to a number of differentially constrained oxotremorine analogues as muscarinic agents.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::f372debaf43a82bd58e50252437570c4 https://doi.org/10.1016/s0040-4039(00)94471-x Zobrazit plný text záznamu